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BRIEF RESEARCH REPORT article

Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1465836
This article is part of the Research Topic Cellular and Molecular Mechanisms that Govern Assembly, Plasticity, and Function of GABAergic Inhibitory Circuits in the Mammalian Brain View all 7 articles

Vasoactive Intestinal Peptide-Expressing Interneurons Modulate the Effect of Behavioral State on Cortical Activity

Provisionally accepted
Mohammad Mahdi Sabri Mohammad Mahdi Sabri Renata Batista-Brito Renata Batista-Brito *
  • Albert Einstein College of Medicine, New York City, United States

The final, formatted version of the article will be published soon.

    Animals live in a complex and changing environment with various degrees of behavioral demands.Behavioral states affect the activity of cortical neurons and the dynamics of neuronal populations, however not much is known about the cortical circuitry behind the modulation of neuronal activity across behavioral states. Here we show that a class of GABAergic inhibitory interneurons that express vasoactive intestinal peptide-expressing interneurons (VIP), namely VIP interneurons, play a key role in the circuits involved in the modulation of cortical activity by behavioral state, as reflected in the mice facial motion. We show that inhibition of VIP interneurons reduces the correlated activity between the behavioral state of the animal and the spiking of individual neurons.We also show that VIP inhibition during the quiet state decreases the synchronous spiking of the neurons but increases delta power and phase locking of spiking to the delta-band activity.Taken together our data show that VIP interneurons modulate the behavioral state-dependency of cortical activity across different time scales.

    Keywords: Cortical state, behavioral state, VIP interneurons, spiking synchrony, Delta power

    Received: 16 Jul 2024; Accepted: 23 Aug 2024.

    Copyright: © 2024 Sabri and Batista-Brito. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Renata Batista-Brito, Albert Einstein College of Medicine, New York City, United States

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