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REVIEW article

Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1464595

Circadian rhythm disruption: A potential trigger in Parkinson's Disease pathogenesis

Provisionally accepted
Ke Xu Ke Xu 1Yu Zhang Yu Zhang 1Yue Shi Yue Shi 1Yake Zhang Yake Zhang 1*Chengguang Zhang Chengguang Zhang 1Tianjiao Wang Tianjiao Wang 1*Peizhu Lv Peizhu Lv 1*Yan Bai Yan Bai 2*Shun Wang Shun Wang 1*
  • 1 Heilongjiang University of Chinese Medicine, Harbin, China
  • 2 Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang Province, China

The final, formatted version of the article will be published soon.

    Parkinson's disease (PD) is a neurodegenerative disease characterized by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), abnormal accumulation of αsynuclein (α-syn), and activation of microglia leading to neuroinflammation. Disturbances in circadian rhythm play a significant role in PD, with most non-motor symptoms associated with disruptions in circadian rhythm. These disturbances can be observed years before motor symptoms appear and are marked by the emergence of non-motor symptoms related to PD, such as rapid eye movement sleep behavior disorder (RBD), restless leg syndrome (RLS), excessive daytime sleepiness (EDS), depression and anxiety, changes in blood pressure, gastrointestinal dysfunction, and urinary problems. Circadian rhythm disruption precedes the onset of motor symptoms and contributes to the progression of PD. In brief, this article outlines the role of circadian rhythm disruption in triggering PD at cellular and molecular levels, as well as its clinical manifestations. It also explores how circadian rhythm research can contribute to preventing the onset and progression of PD from current and future perspectives.

    Keywords: Circadian Rhythm, Parkinson's disease (PD), Dopamine (DA), Microglia, αsynuclein (α-syn), Non-motor symptom

    Received: 14 Jul 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Xu, Zhang, Shi, Zhang, Zhang, Wang, Lv, Bai and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yake Zhang, Heilongjiang University of Chinese Medicine, Harbin, China
    Tianjiao Wang, Heilongjiang University of Chinese Medicine, Harbin, China
    Peizhu Lv, Heilongjiang University of Chinese Medicine, Harbin, China
    Yan Bai, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang Province, China
    Shun Wang, Heilongjiang University of Chinese Medicine, Harbin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.