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REVIEW article

Front. Cell. Neurosci.
Sec. Cellular Neuropathology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1456775
This article is part of the Research Topic The Contribution of the Neurovascular Unit in Neuroinflammatory Disease: Insights, Mechanisms, and Therapeutic Implications View all articles

Potential Role of Endothelial Progenitor Cells in The Pathogenesis and Treatment of Cerebral Aneurysm

Provisionally accepted
Jin Yu Jin Yu 1Qian Du Qian Du 1Yuncun Fan Yuncun Fan 2Jianjian Zhang Jianjian Zhang 1Jincao Chen Jincao Chen 1*
  • 1 Zhongnan Hospital, Wuhan University, Wuhan, China
  • 2 Laifeng People's Hospital, Enshi, China

The final, formatted version of the article will be published soon.

    Cerebral aneurysm (CA) is a significant health concern that results from pathological dilations of blood vessels in the brain and can lead to severe and potentially life-threatening conditions. While the pathogenesis of CA is complex, emerging studies suggest that endothelial progenitor cells (EPCs) play a crucial role. In this paper, we conducted a comprehensive literature review to investigate the potential role of EPCs in the pathogenesis and treatment of CA. Current research indicates that a decreased count and dysfunction of EPCs disrupt the balance between endothelial dysfunction and repair, thus increasing the risk of CA formation. Reversing these EPCs abnormalities may reduce the progression of vascular degeneration after aneurysm induction, indicating EPCs as a promising target for developing new therapeutic strategies to facilitate CA repair. This has motivated researchers to develop novel treatment options, including drug applications, endovascular-combined and tissue engineering therapies. Although preclinical studies have shown promising results, there is still a considerable way to go before clinical translation and eventual benefits for patients.Nonetheless, these findings offer hope for improving the treatment and management of this condition.

    Keywords: endothelial progenitor cells, Cerebral aneurysm, endothelial dysfunction, endothelialization, Endovascular Therapy

    Received: 29 Jun 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Yu, Du, Fan, Zhang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jincao Chen, Zhongnan Hospital, Wuhan University, Wuhan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.