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REVIEW article

Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1441806

Piezo1: The Key Regulators in Central Nervous System Diseases

Provisionally accepted
Yi Xu Yi Xu 1Yuheng Wang Yuheng Wang 1Yanling Yang Yanling Yang 1Xiaowei Fang Xiaowei Fang 2Lidong Wu Lidong Wu 2Jin Li Jin Li 2Jialing Hu Jialing Hu 2*Shuchong Mei Shuchong Mei 2
  • 1 Nanchang University, Nanchang, Jiangxi Province, China
  • 2 Department of Emergency Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China

The final, formatted version of the article will be published soon.

    The occurrence and development of central nervous system (CNS) diseases is a multi-factor and multi-gene pathological process, and their diagnosis and treatment have always posed a serious challenge in the medical field.Therefore, exploring the relevant factors in the pathogenesis of CNS and improving the diagnosis and treatment rates has become an urgent problem.Piezo1 is a recently discovered mechanosensitive ion channel that opens in response to mechanical stimuli. A number of previous studies have shown that the Piezo channel family plays a crucial role in CNS physiology and pathology, especially in diseases related to CNS development and mechanical stimulation. This article comprehensively describes the biological properties of Piezo1, focuses on the potential association between Piezo1 and CNS disorders, and explores the pharmacological roles of Piezo1 agonists and inhibitors in treating CNS disorders.

    Keywords: Piezo1, CNS diseases, Biological properties, Ca2+, Pharmacology

    Received: 31 May 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Xu, Wang, Yang, Fang, Wu, Li, Hu and Mei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jialing Hu, Department of Emergency Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.