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MINI REVIEW article

Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 18 - 2024 | doi: 10.3389/fncel.2024.1427525

Therapeutic potential of mesenchymal stem cell-Derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: A Mini Review

Provisionally accepted
Aria Salehpour Aria Salehpour 1Zahra Karimi Zahra Karimi 1Ghasemi Zadeh Ghasemi Zadeh 1,2Mohammadreza Afshar Mohammadreza Afshar 1Ali Kameli Ali Kameli 1Fatemeh Mooseli Fatemeh Mooseli 1,2Masoud Zare Masoud Zare 1Alireza Afshar Alireza Afshar 1,2*
  • 1 Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
  • 2 Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Bushehr, Iran

The final, formatted version of the article will be published soon.

    Mesenchymal stem cells (MSCs) have gained considerable attention in the field of regenerative medicine due to their ability to secrete small extracellular vesicles (EVs) known as exosomes. This review delves into the various biological activities of MSCs and the cell interactions enabled by these exosomes, with a focus on their potential for neuronal regeneration and the treatment of neurological disorders. We scrutinize findings from multiple studies that underscore the neuroprotective and neuro-regenerative effects of exosomes derived from MSCs, illuminating their mechanisms of action and therapeutic applications. This review thoroughly investigates all related pathways, miRNAs, and factors to suggest potential strategies for enhancing therapy for neurological disorders using exosomes and miRNAs, and for boosting neuronal regeneration.

    Keywords: keyword1, keyword2, keyword3, keyword4, keyword5. (Min.5-Max. 8 Neurological Disorders, Exosomes, Mesenchymal Stem Cells, MSCs

    Received: 03 May 2024; Accepted: 24 Sep 2024.

    Copyright: © 2024 Salehpour, Karimi, Zadeh, Afshar, Kameli, Mooseli, Zare and Afshar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Alireza Afshar, Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.