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ORIGINAL RESEARCH article
Front. Cell. Neurosci.
Sec. Cellular Neurophysiology
Volume 18 - 2024 |
doi: 10.3389/fncel.2024.1412897
Regional heterogeneity in the membrane properties of mouse striatal neurons
Provisionally accepted- 1 Columbia University, New York City, United States
- 2 New York State Psychiatric Institute (NYSPI), New York, New York, United States
The cytoarchitecture of the striatum is remarkably homogeneous, in contrast to the regional variation in striatal functions. Whether differences in the intrinsic membrane properties of striatal neurons contribute to regional heterogeneity has not been addressed systematically. We made recordings throughout the young adult mouse striatum, under identical conditions, with synaptic input blocked, from four major striatal neuron types: the two subtypes of spiny projection neurons (SPNs), cholinergic interneurons (ChIs), and fast-spiking GABAergic interneurons (FSIs), sampling at least 100 cells per cell type. Regional variation manifested across all cell types. All cell types in the nucleus accumbens (NAc) shell had higher input impedance and increased excitability. Cells in the NAc core were differentiated from the caudate-putamen (CPu) for both SPN subtypes by smaller action potentials and increased excitability. Similarity between the two SPN subtypes showed regional variation, differing more in the NAc than the CPu. So, in the Str both the intrinsic properties of interneurons and projection neurons are regionally heterogeneous, with the greatest difference between the NAc and CPu; greater excitability of NAc shell neurons may make the region more susceptible to activity-dependent plasticity.
Keywords: Membrane properties, excitability, Spiny projection neurons, cholinergic interneurons, fast-spiking interneurons, Striatum, multivariate analysis
Received: 05 Apr 2024; Accepted: 19 Jun 2024.
Copyright: © 2024 Chuhma and Rayport. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nao Chuhma, Columbia University, New York City, United States
Stephen Rayport, Columbia University, New York City, United States
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