AUTHOR=Chen Ke-qian , Wang Shu-zhi , Lei Hai-bo , Liu Xiang 

TITLE=Necrostatin-1: a promising compound for neurological disorders

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=18

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1408364

DOI=10.3389/fncel.2024.1408364

ISSN=1662-5102

ABSTRACT=<p>Necrostatin-1, a small molecular alkaloid, was identified as an inhibitor of necroptosis in 2005. Investigating the fundamental mechanism of Necrostatin-1 and its role in various diseases is of great significance for scientific and clinical research. Accumulating evidence suggests that Necrostatin-1 plays a crucial role in numerous neurological disorders. This review aims to provide a comprehensive overview of the potential functions of Necrostatin-1 in various neurological disorders, offering valuable insights for future research.</p>