AUTHOR=Urrutia Janire , Arrizabalaga-Iriondo Ane , Sanchez-del-Rey Ana , Martinez-Ibargüen Agustín , Gallego Mónica , Casis Oscar , Revuelta Miren 

TITLE=Therapeutic role of voltage-gated potassium channels in age-related neurodegenerative diseases

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=18

YEAR=2024

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1406709

DOI=10.3389/fncel.2024.1406709

ISSN=1662-5102

ABSTRACT=<p>Voltage-gated ion channels are essential for membrane potential maintenance, homeostasis, electrical signal production and controlling the Ca<sup>2+</sup> flow through the membrane. Among all ion channels, the key regulators of neuronal excitability are the voltage-gated potassium channels (K<sub>V</sub>), the largest family of K<sup>+</sup> channels. Due to the ROS high levels in the aging brain, K<sup>+</sup> channels might be affected by oxidative agents and be key in aging and neurodegeneration processes. This review provides new insight about channelopathies in the most studied neurodegenerative disorders, such as Alzheimer Disease, Parkinson’s Disease, Huntington Disease or Spinocerebellar Ataxia. The main affected K<sub>V</sub> channels in these neurodegenerative diseases are the K<sub>V</sub>1, K<sub>V</sub>2.1, K<sub>V</sub>3, K<sub>V</sub>4 and K<sub>V</sub>7. Moreover, in order to prevent or repair the development of these neurodegenerative diseases, previous K<sub>V</sub> channel modulators have been proposed as therapeutic targets.</p>