AUTHOR=Wang Hsien-Chu , Phan Thi-Nhan , Kao Chi-Ling , Yeh Chih-Kuang , Lin Yu-Chun TITLE=Genetically encoded mediators for sonogenetics and their applications in neuromodulation JOURNAL=Frontiers in Cellular Neuroscience VOLUME=17 YEAR=2023 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2023.1326279 DOI=10.3389/fncel.2023.1326279 ISSN=1662-5102 ABSTRACT=

Sonogenetics is an emerging approach that harnesses ultrasound for the manipulation of genetically modified cells. The great penetrability of ultrasound waves enables the non-invasive application of external stimuli to deep tissues, particularly advantageous for brain stimulation. Genetically encoded ultrasound mediators, a set of proteins that respond to ultrasound-induced bio-effects, play a critical role in determining the effectiveness and applications of sonogenetics. In this context, we will provide an overview of these ultrasound-responsive mediators, delve into the molecular mechanisms governing their response to ultrasound stimulation, and summarize their applications in neuromodulation.