AUTHOR=Tam Hoi Hei , Zhu Dongxing , Ho Samuel Sze King , Vong Heng Wai , Wong Vincent Kam Wai , Mok Simon Wing-Fai , Wong Io Nam TITLE=Potential enhancement of post-stroke angiogenic response by targeting the oligomeric aggregation of p53 protein JOURNAL=Frontiers in Cellular Neuroscience VOLUME=17 YEAR=2023 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2023.1193362 DOI=10.3389/fncel.2023.1193362 ISSN=1662-5102 ABSTRACT=

Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible p53 aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia and the presence of reactive oxygen species (ROS). The angiogenic pathways involving p53 mainly occur in nucleus or cytoplasm, with one exception that occurs in mitochondria. Considering the high mitochondrial density in brain and endothelial cells, we proposed that the cyclophilin D (CypD)-dependent vascular endothelial cell (VECs) necrosis pathway occurring in the mitochondria is one of the major factors that affects angiogenesis. Hence, targeting p53 aggregation, a key intermediate in the pathway, could be an alternative therapeutic target for post-stroke management.