AUTHOR=Han Hezhou , Hu Sainan , Hu Yue , Liu Dongliang , Zhou Junbo , Liu Xiaofang , Ma Xiulan , Dong Yaodong TITLE=Mitophagy in ototoxicity JOURNAL=Frontiers in Cellular Neuroscience VOLUME=17 YEAR=2023 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2023.1140916 DOI=10.3389/fncel.2023.1140916 ISSN=1662-5102 ABSTRACT=

Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and signaling pathways. The results of ototoxicity models indicate the importance of this process in the etiology of ototoxicity. A number of recent investigations of the control of cell fate by mitophagy have enhanced our understanding of the mechanisms by which mitophagy regulates ototoxicity and other hearing-related diseases, providing opportunities for targeting mitochondria to treat ototoxicity.