AUTHOR=García Octavio , Flores-Aguilar Lisi TITLE=Astroglial and microglial pathology in Down syndrome: Focus on Alzheimer's disease JOURNAL=Frontiers in Cellular Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2022.987212 DOI=10.3389/fncel.2022.987212 ISSN=1662-5102 ABSTRACT=
Down syndrome (DS) arises from the triplication of human chromosome 21 and is considered the most common genetic cause of intellectual disability. Glial cells, specifically astroglia and microglia, display pathological alterations that might contribute to DS neuropathological alterations. Further, in middle adulthood, people with DS develop clinical symptoms associated with premature aging and Alzheimer's disease (AD). Overexpression of the amyloid precursor protein (