AUTHOR=Zhang Yunsha , Lian Lu , Fu Rong , Liu Jueling , Shan Xiaoqian , Jin Yang , Xu Shixin 

TITLE=Microglia: The Hub of Intercellular Communication in Ischemic Stroke

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2022.889442

DOI=10.3389/fncel.2022.889442

ISSN=1662-5102

ABSTRACT=<p>Communication between microglia and other cells has recently been at the forefront of research in central nervous system (CNS) disease. In this review, we provide an overview of the neuroinflammation mediated by microglia, highlight recent studies of crosstalk between microglia and CNS resident and infiltrating cells in the context of ischemic stroke (IS), and discuss how these interactions affect the course of IS. The in-depth exploration of microglia-intercellular communication will be beneficial for therapeutic tools development and clinical translation for stroke control.</p>