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CORRECTION article

Front. Cell. Neurosci., 15 December 2022
Sec. Cellular Neurophysiology
Volume 16 - 2022 | https://doi.org/10.3389/fncel.2022.1022297

Corrigendum: Combination therapy with fingolimod and neural stem cells promotes functional myelination in vivo through a non-immunomodulatory mechanism

This article is a correction to:

  1. Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination in vivo Through a Non-immunomodulatory Mechanism

    1. Read original article
\nYuan Zhang,Yuan Zhang1,2Xin-Yu LuXin-Yu Lu2Ze-Qin YeZe-Qin Ye2Bogoljub CiricBogoljub Ciric1Cun-Gen MaCun-Gen Ma3Abdolmohamad RostamiAbdolmohamad Rostami1Xing Li, Xing Li1,2*Guang-Xian Zhang Guang-Xian Zhang1*
  • 1Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States
  • 2National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education, Shaanxi Normal University, Xi'an, China
  • 3Department of Neurology, Institute of Brain Science, Shanxi Datong University Medical School, Datong, China

A corrigendum on
Combination therapy with fingolimod and neural stem cells promotes functional myelination in vivo through a non-immunomodulatory mechanism

by Zhang, Y., Lu, X.-Y., Ye, Z.-Q., Ciric, B., Ma, C.-G., Rostami, A., Li, X., and Zhang, G.-X. (2019). Front. Cell. Neurosci. 13:14. doi: 10.3389/fncel.2019.00014

In the published article, there was an error in Figure 2 as published. Due to a mistake made during figure preparation, there was an error in the CC1-GFP-stained image in the PBS and FTY720 group of Figure 2B. The corrected Figure 2 and its caption appears below.

FIGURE 2
www.frontiersin.org

Figure 2. Impact of FTY720 plus NSC treatment on neural cell lineages in brain slice culture model. Brain slices obtained from newborn (P0-3) C57/Bl6 mouse pups were grown for 3 days in culture, and NSCs (2 μl, ~5 × 104 cells /slice) and/or FTY720 (1 nM) were added for the subsequent 7 days; the slices were then fixed and immunostained. (A) Quantitative analysis of the number of transplanted NSCs (GFP+) in brain slices. (B) Immunofluorescence images of brain slices. Cells co-labeled with GFP and neural specific markers (red) were identified as differentiated cells derived from NSCs (yellow); cells positive only for neural-specific markers (red) were endogenous cells. CC1+: oligodendrocytes, NeuN+: neurons, GFAP+, astrocytes. Scale bar = 20 μm. (C) High-magnification confocal images show that GFP (green) was highly colocalized with the oligodendrocyte marker MBP (red). Scale bar = 10 μm. (D) Quantification of total CC1+ cell numbers. (E) Quantitative analysis of differentiation of transplanted NSCs in the CNS as shown in (B). Symbols represent mean ± SD; n = 10 random areas per group. ***p < 0.001. One-way ANOVA with Tukey's multiple comparisons test and unpaired Student's t-test. One representative of 3 independent experiments is shown.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: fingolimod, neural stem cells, myelination, oligodendrocytes, combination therapy

Citation: Zhang Y, Lu X-Y, Ye Z-Q, Ciric B, Ma C-G, Rostami A, Li X and Zhang G-X (2022) Corrigendum: Combination therapy with fingolimod and neural stem cells promotes functional myelination in vivo through a non-immunomodulatory mechanism. Front. Cell. Neurosci. 16:1022297. doi: 10.3389/fncel.2022.1022297

Received: 18 August 2022; Accepted: 29 November 2022;
Published: 15 December 2022.

Edited and reviewed by: Stefania Ceruti, University of Milan, Italy

Copyright © 2022 Zhang, Lu, Ye, Ciric, Ma, Rostami, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Xing Li, yes xingli_xian@126.com; Guang-Xian Zhang, yes guang-xian.zhang@jefferson.edu

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.