AUTHOR=Chen Yahong , Zhu Jie , Ji Jingjing , Liu Zhifeng , Ren Guangli 

TITLE=The role of microglial exosomes in brain injury

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2022.1003809

DOI=10.3389/fncel.2022.1003809

ISSN=1662-5102

ABSTRACT=Microglia are involved in the physiological and pathological processes of nervous system. In addition, exosomes derived from microglia are also involved in the immune response of the central nervous system. However, their specific mechanism is still unknown. We elucidated microglial exosome characteristics, release patterns, pro-proliferative and pro-apoptotic effects on neurons and other glial cells, immunomodulatory effects and regulation of the extracellular microenvironment. Understanding the relationship between microglia exosomes and brain injury can provide new targets for clinical treatment.