AUTHOR=Pucci Susanna , Zoli Michele , Clementi Francesco , Gotti Cecilia 

TITLE=α9-Containing Nicotinic Receptors in Cancer

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=15

YEAR=2022

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.805123

DOI=10.3389/fncel.2021.805123

ISSN=1662-5102

ABSTRACT=<p>Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly express α9-containing receptors, and a number of studies have shown that they are powerful regulators of responses that stimulate cancer processes such as proliferation, inhibition of apoptosis, and metastasis. It has also emerged that their modulation is a promising target for drug development. The aim of this review is to summarize recent data showing the involvement of these receptors in controlling the downstream signaling cascades involved in the promotion of cancer.</p>