AUTHOR=Olmsted Zachary T. , Stigliano Cinzia , Marzullo Brandon , Cibelli Jose , Horner Philip J. , Paluh Janet L. TITLE=Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive Without Neuroprotection in the Spinal Contusion Cavity JOURNAL=Frontiers in Cellular Neuroscience VOLUME=15 YEAR=2022 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.725195 DOI=10.3389/fncel.2021.725195 ISSN=1662-5102 ABSTRACT=
Neural cell interventions in spinal cord injury (SCI) have focused predominantly on transplanted multipotent neural stem/progenitor cells (NSPCs) for animal research and clinical use due to limited information on survival of spinal neurons. However, transplanted NSPC fate is unpredictable and largely governed by injury-derived matrix and cytokine factors that are often gliogenic and inflammatory. Here, using a rat cervical hemicontusion model, we evaluate the survival and integration of hiPSC-derived spinal motor neurons (SMNs) and oligodendrocyte progenitor cells (OPCs). SMNs and OPCs were differentiated