AUTHOR=Vielle Anne , Park Yuna K. , Secora Conner , Vergara M. Natalia 

TITLE=Organoids for the Study of Retinal Development and Developmental Abnormalities

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.667880

DOI=10.3389/fncel.2021.667880

ISSN=1662-5102

ABSTRACT=<p>The cumulative knowledge of retina development has been instrumental in the generation of retinal organoid systems from pluripotent stem cells; and these three-dimensional organoid models, in turn, have provided unprecedented opportunities for retinal research and translational applications, including the ability to model disease in a human setting and to apply these models to the development and validation of therapeutic drugs. In this review article, we examine how retinal organoids can also contribute to our understanding of retinal developmental mechanisms, how this knowledge can be applied to modeling developmental abnormalities, and highlight some of the avenues that remain to be explored.</p>