AUTHOR=Warepam Marina , Mishra Awdhesh Kumar , Sharma Gurumayum Suraj , Kumari Kritika , Krishna Snigdha , Khan Mohd Sajjad Ahmad , Rahman Hamidur , Singh Laishram Rajendrakumar 

TITLE=Brain Metabolite, N-Acetylaspartate Is a Potent Protein Aggregation Inhibitor

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.617308

DOI=10.3389/fncel.2021.617308

ISSN=1662-5102

ABSTRACT=<p>Deposition of toxic protein inclusions is a common hallmark of many neurodegenerative disorders including Alzheimer's disease, Parkinson disease etc. N-acetylaspartate (NAA) is an important brain metabolite whose levels got altered under various neurodegenerative conditions. Indeed, NAA has been a widely accepted biological marker for various neurological disorders. We have also reported that NAA is a protein stabilizer. In the present communication, we investigated the role of NAA in modulating the aggregation propensity on two model proteins (carbonic anhydrase and catalase). We discovered that NAA suppresses protein aggregation and could solubilize preformed aggregates.</p>