AUTHOR=Xuan Fang-Ling , Chithanathan Keerthana , Lilleväli Kersti , Yuan Xiaodong , Tian Li 

TITLE=Differences of Microglia in the Brain and the Spinal Cord

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=13

YEAR=2019

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2019.00504

DOI=10.3389/fncel.2019.00504

ISSN=1662-5102

ABSTRACT=<p>Microglia were previously regarded as a homogenous myeloid cell lineage in the mammalian central nervous system (CNS). However, accumulating evidences show that microglia in the brain and SC are quite different in development, cellular phenotypes and biological functions. Although this is a very interesting phenomenon, the underlying mechanisms and its significance for neurological diseases in association with behavioral and cognitive changes are still unclear. How microglia differ between these two regions and whether such diversity may contribute to CNS development and functions as well as neurological diseases will be discussed in this Perspective.</p>