AUTHOR=Zhang Yuan , Zhao Yanfang , Zhang Lei , Yu Wanpeng , Wang Yu , Chang Wenguang 

TITLE=Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer’s Disease

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=13

YEAR=2019

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2019.00339

DOI=10.3389/fncel.2019.00339

ISSN=1662-5102

ABSTRACT=<p>The pathological features of Alzheimer’s disease (AD) include senile plaques induced by amyloid-β (Aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. Recent observations have suggested the possibility of an association between AD and cellular prion protein (PrP<sup><italic>C</italic></sup>) levels. PrP<sup><italic>C</italic></sup> is a high affinity receptor for oligomeric Aβ and is important for Aβ-induced neurotoxicity and thus plays a critical role in AD pathogenesis. The determination of the relationship between PrP<sup><italic>C</italic></sup> and AD and the characterization of PrP<sup><italic>C</italic></sup> binding to Aβ will facilitate the development of novel therapies for AD.</p>