AUTHOR=Li Yanan , Xie Xin’e , Xing Hang , Yuan Xiang , Wang Yuan , Jin Yikai , Wang Jiangang , Vreugdenhil Martin , Zhao Ying , Zhang Ruiling , Lu Chengbiao 

TITLE=The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=13

YEAR=2019

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2019.00277

DOI=10.3389/fncel.2019.00277

ISSN=1662-5102

ABSTRACT=<p>Gamma frequency oscillations (γ, 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on γ oscillations. We explored the effects of multiple intracellular kinases on MA modulation of γ induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and <italic>N</italic>-methyl-<sc>D</sc>-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on γ oscillations, whereas none of them affected baseline γ strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of γ oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.</p>