AUTHOR=Roselló-Busquets Cristina , de la Oliva Natalia , Martínez-Mármol Ramón , Hernaiz-Llorens Marc , Pascual Marta , Muhaisen Ashraf , Navarro Xavier , del Valle Jaume , Soriano Eduardo TITLE=Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration JOURNAL=Frontiers in Cellular Neuroscience VOLUME=13 YEAR=2019 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2019.00040 DOI=10.3389/fncel.2019.00040 ISSN=1662-5102 ABSTRACT=
Axonal growth during normal development and axonal regeneration rely on the action of many receptor signaling systems and complexes, most of them located in specialized raft membrane microdomains with a precise lipid composition. Cholesterol is a component of membrane rafts and the integrity of these structures depends on the concentrations present of this compound. Here we explored the effect of cholesterol depletion in both developing neurons and regenerating axons. First, we show that cholesterol depletion