AUTHOR=Bachiller Sara , Jiménez-Ferrer Itzia , Paulus Agnes , Yang Yiyi , Swanberg Maria , Deierborg Tomas , Boza-Serrano Antonio 

TITLE=Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=12

YEAR=2018

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00488

DOI=10.3389/fncel.2018.00488

ISSN=1662-5102

ABSTRACT=<p>Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization, trophic neuronal support during development, phagocytosis of apoptotic cells in the developing brain, myelin turnover, control of neuronal excitability, phagocytic debris removal as well as brain protection and repair. Microglial response is pathology dependent and affects to immune, metabolic. In this review, we will shed light on microglial activation depending on the disease context and the influence of factors such as aging, environment or cell-to-cell interaction.</p>