AUTHOR=Wang Jiancai , Li Yuqian , Gao Li , Yan Fengqi , Gao Guodong , Li Lihong 

TITLE=GSK-3β Inhibitor Alsterpaullone Attenuates MPP+-Induced Cell Damage in a c-Myc-Dependent Manner in SH-SY5Y Cells

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=12

YEAR=2018

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00283

DOI=10.3389/fncel.2018.00283

ISSN=1662-5102

ABSTRACT=<p>Mitochondrial dysfunction plays significant roles in the pathogenesis of Parkinson’s Disease (PD). The inactivation of c-Myc, a down-stream gene of Wnt/β-catenin signaling, may contribute to the mitochondria dysfunction. Inhibition of glycogen synthase kinase 3β (GSK-3β) with Alsterpaullone (Als) can activate the down-stream events of Wnt signaling. Here, we investigated the protective roles of Als against MPP<sup>+</sup>-induced cell apoptosis in SH-SY5Y cells. The data showed that Als effectively rescued c-Myc from the MPP<sup>+</sup>-induced decline via Wnt signaling. Furthermore, Als protected SH-SY5Y cells from the MPP<sup>+</sup>-induced mitochondrial fission and cell apoptosis. However, the protective roles of Als were lost under β-catenin-deficient conditions. These findings indicate that Als, a GSK-3β inhibitor, attenuated the MPP<sup>+</sup>-induced mitochondria-dependent apoptotic via up-regulation of the Wnt signaling.</p>