AUTHOR=Vásquez-Navarrete Jacqueline , Martínez Agustín D. , Ory Stéphane , Baéz-Matus Ximena , González-Jamett Arlek M. , Brauchi Sebastián , Caviedes Pablo , Cárdenas Ana M. TITLE=RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome JOURNAL=Frontiers in Cellular Neuroscience VOLUME=12 YEAR=2018 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00189 DOI=10.3389/fncel.2018.00189 ISSN=1662-5102 ABSTRACT=
In humans, Down Syndrome (DS) is a condition caused by partial or full trisomy of chromosome 21. Genes present in the DS critical region can result in excess gene dosage, which at least partially can account for DS phenotype. Although regulator of calcineurin 1 (RCAN1) belongs to this region and its ectopic overexpression in neurons impairs transmitter release, synaptic plasticity, learning and memory, the relative contribution of RCAN1 in a context of DS has yet to be clarified. In the present work, we utilized an