AUTHOR=Wang Jun , Zhai Weiwei , Yu Zhengquan , Sun Liang , Li Haiying , Shen Haitao , Li Xiang , Liu Chunfeng , Chen Gang TITLE=Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats JOURNAL=Frontiers in Cellular Neuroscience VOLUME=11 YEAR=2018 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2017.00432 DOI=10.3389/fncel.2017.00432 ISSN=1662-5102 ABSTRACT=
Binding of extracellular netrin-1 to its receptors, deleted in colorectal cancer (DCC) and uncoordinated gene 5H2 (UNC5H2), inhibits apoptosis mediated by these receptors. A neuron-specific kinesin motor protein, KIF1A, has been shown to participate in netrin-1 secretion. This study aimed to identify the roles of netrin-1 and KIF1A in secondary brain injury after intracerebral hemorrhage (ICH) and the potential mechanisms. An autologous blood ICH model was established in adult male Sprague-Dawley rats, and cultured neurons were exposed to OxyHb to mimic ICH conditions