AUTHOR=Ilmoniemi Risto J. , Mäki Hanna , Saari Jukka , Salvador Ricardo , Miranda Pedro C. 

TITLE=The Frequency-Dependent Neuronal Length Constant in Transcranial Magnetic Stimulation

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=10

YEAR=2016

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2016.00194

DOI=10.3389/fncel.2016.00194

ISSN=1662-5102

ABSTRACT=<p><bold>Background:</bold> The behavior of the dendritic or axonal membrane voltage due to transcranial magnetic stimulation (TMS) is often modeled with the one-dimensional cable equation. For the cable equation, a length constant λ<sub>0</sub> is defined; λ<sub>0</sub> describes the axial decay of the membrane voltage in the case of constant applied electric field. In TMS, however, the induced electric field waveform is typically a segment of a sinusoidal wave, with characteristic frequencies of the order of several kHz.</p><p><bold>Objective:</bold> To show that the high frequency content of the stimulation pulse causes deviations in the spatial profile of the membrane voltage as compared to the steady state.</p><p><bold>Methods:</bold> We derive the cable equation in complex form utilizing the complex frequency-dependent representation of the membrane conductivity. In addition, we define an effective length constant λ<sub>eff</sub>, which governs the spatial decay of the membrane voltage. We model the behavior of a dendrite in an applied electric field oscillating at 3.9 kHz with the complex cable equation and by solving the traditional cable equation numerically.</p><p><bold>Results:</bold> The effective length constant decreases as a function of frequency. For a model dendrite or axon, for which λ<sub>0</sub> = 1.5 mm, the effective length constant at 3.9 kHz is decreased by a factor 10 to 0.13 mm.</p><p><bold>Conclusion:</bold> The frequency dependency of the neuronal length constant has to be taken into account when predicting the spatial behavior of the membrane voltage as a response to TMS.</p>