AUTHOR=Bayer Andersen Kirsten , Leander Johansen Jens , Hentzer Morten , Smith Garrick Paul , Dietz Gunnar P. H. TITLE=Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP+ and Rotenone Toxicity JOURNAL=Frontiers in Cellular Neuroscience VOLUME=10 YEAR=2016 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2016.00164 DOI=10.3389/fncel.2016.00164 ISSN=1662-5102 ABSTRACT=
The G-protein coupled receptor 139 (GPR139) is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. Here, we examined the potential neuroprotective effect of GPR139 agonism in primary culture models of dopaminergic (DA) neuronal degeneration. We find that