AUTHOR=Fernandes Carina , Rocha Nuno Barbosa F. , Rocha Susana , Herrera-Solís Andrea , Salas-Pacheco José , García-García Fabio , Murillo-Rodríguez Eric , Yuan Ti-Fei , Machado Sergio , Arias-Carrión Oscar TITLE=Detrimental role of prolonged sleep deprivation on adult neurogenesis JOURNAL=Frontiers in Cellular Neuroscience VOLUME=9 YEAR=2015 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2015.00140 DOI=10.3389/fncel.2015.00140 ISSN=1662-5102 ABSTRACT=

Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.