AUTHOR=Benakis Corinne , Garcia-Bonilla Lidia , Iadecola Costantino , Anrather Josef 

TITLE=The role of microglia and myeloid immune cells in acute cerebral ischemia

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=8

YEAR=2015

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2014.00461

DOI=10.3389/fncel.2014.00461

ISSN=1662-5102

ABSTRACT=<p>The immune response to acute cerebral ischemia is a major contributor to stroke pathobiology. The inflammatory response is characterized by the participation of brain resident cells and peripheral leukocytes. Microglia in the brain and monocytes/neutrophils in the periphery have a prominent role in initiating, sustaining and resolving post-ischemic inflammation. In this review we aim to summarize recent literature concerning the origins, fate and role of microglia, monocytes and neutrophils in models of cerebral ischemia and to discuss their relevance for human stroke.</p>