AUTHOR=Goldie Belinda J. , Barnett Michelle M. , Cairns Murray J. TITLE=BDNF and the maturation of posttranscriptional regulatory networks in human SH-SY5Y neuroblast differentiation JOURNAL=Frontiers in Cellular Neuroscience VOLUME=8 YEAR=2014 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2014.00325 DOI=10.3389/fncel.2014.00325 ISSN=1662-5102 ABSTRACT=
The SH-SY5Y culture system is a convenient neuronal model with the potential to elaborate human/primate-specific transcription networks and pathways related to human cognitive disorders. While this system allows for the exploration of specialized features in the human genome, there is still significant debate about how this model should be implemented, and its appropriateness for answering complex functional questions related to human neural architecture. In view of these questions we sought to characterize the posttranscriptional regulatory structure of the two-stage ATRA differentiation, BDNF maturation protocol proposed by Encinas et al. (