AUTHOR=Meier Jochen C. , Semtner Marcus , Winkelmann Aline , Wolfart Jakob 

TITLE=Presynaptic mechanisms of neuronal plasticity and their role in epilepsy

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=8

YEAR=2014

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2014.00164

DOI=10.3389/fncel.2014.00164

ISSN=1662-5102

ABSTRACT=<p>Synaptic communication requires constant adjustments of pre- and postsynaptic efficacies. In addition to synaptic long term plasticity, the presynaptic machinery underlies homeostatic regulations which prevent out of range transmitter release. In this minireview we will discuss the relevance of selected presynaptic mechanisms to epilepsy including voltage- and ligand-gated ion channels as well as cannabinoid and adenosine receptor signaling.</p>