AUTHOR=Sava Bogdan A., Chen Rongqing , Sun Haiyan , Luhmann Heiko J., Kilb Werner TITLE=Taurine activates GABAergic networks in the neocortex of immature mice JOURNAL=Frontiers in Cellular Neuroscience VOLUME=Volume 8 - 2014 YEAR=2014 URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2014.00026 DOI=10.3389/fncel.2014.00026 ISSN=1662-5102 ABSTRACT=
Although it has been suggested that taurine is the main endogenous neurotransmitter acting on glycine receptors, the implications of glycine receptor-mediated taurine actions on immature neocortical networks have not been addressed yet. To investigate the influence of taurine on the excitability of neuronal networks in the immature neocortex, we performed whole-cell patch-clamp recordings from visually identified pyramidal neurons and interneurons in coronal slices from C57Bl/6 and GAD67-green fluorescent protein (GFP) transgenic mice (postnatal days 2–4). In 46% of the pyramidal neurons bath-application of taurine at concentrations ≥ 300 μM significantly enhanced the frequency of postsynaptic currents (PSCs) by 744.3 ± 93.8% (