AUTHOR=Pregno Giulia , Frola Elena , Graziano Stefania , Patrizi Annarita , Bussolino Federico , Arese Marco , Sassoè-Pognetto Marco 

TITLE=Differential regulation of neurexin at glutamatergic and GABAergic synapses

JOURNAL=Frontiers in Cellular Neuroscience

VOLUME=7

YEAR=2013

URL=https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2013.00035

DOI=10.3389/fncel.2013.00035

ISSN=1662-5102

ABSTRACT=<p>Neurexins (Nrxs) have emerged as potential determinants of synaptic specificity, but little is known about their localization at central synapses. Here we show that Nrxs have a remarkably selective localization at distinct types of glutamatergic synapses and we reveal an unexpected ontogenetic regulation of Nrx expression at GABAergic synapses. Our data indicate that synapses are specified by molecular interactions that involve both Nrx-dependent and Nrx-independent mechanisms. We propose that differences in the spatio-temporal profile of Nrx expression may contribute to specify the molecular identity of synapses.</p>