Corrigendum: Exploring the clinical outcomes and molecular characteristics of Acinetobacter baumannii bloodstream infections: a study of sequence types, capsular types, and drug resistance in China

Jiao Chen ^1* Yanting Shao ¹ Zhibin Cheng ¹ Guanghui Li ² Fen Wan ¹ Chenyan Gao ¹ Danqin Wu ³ Dandan Wei ⁴ Yang Liu ⁴ Rong Li ⁵

• ¹ Nanchang Medical College, Nanchang, China
• ² School of Information Engineering, East China Jiaotong University, Nanchang, China
• ³ Neurology Intensive Care Unit (ICU), First Affiliated Hospital of Nanchang University, Nanchang, China
• ⁴ Department of Clinical Microbiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
• ⁵ Department of Clinical Laboratory ,Jiangxi Provincial People's Hospital, Nanchang, China

Results: The 30-day mortality rate of 67 patients with BSIs was 55.22%. Patients in the death group had significantly lower platelet counts and higher CRP levels than those in the survival group. Additionally, higher rates of antibiotic use (≥2 classes) and greater carbapenem exposure were observed. Among the isolates, CRAb accounted for 80.6%, ST2 accounted for 76.12%, and KL2/3/7/77/160 accounted for 65.67%. The predominant KL type was KL3, found in 19.4% of the isolates. All ST2 and KL2/3/7/77/160 isolates were CRAb. Among the isolates, 90.7% of the CRAb isolates coharbored blaOXA-23 and blaOXA-66, while one coharbored blaNDM-1 and blaOXA-23. Compared with non-ST2 and non KL2/3/7/ 77/160 infections, ST2 and KL2/3/7/77/160 infections had higher mortality rates (66.0% vs. 23.5%, P=0.002; 65.90% vs. 34.78%, P=0.015). Patients with ST2 and KL2/3/7/77/160 infections underwent more invasive procedures, received two or more antibiotics and carbapenem therapy before isolation, and had lower serum albumin levels. These isolates exhibited significantly higher resistance to antimicrobial agents. No significant differences in virulence phenotypes were observed between the two groups, except for biofilm formation between the ST2 and non-ST2 groups (P=0.002). However, these isolates harbored more virulence genes related to iron uptake and biofilm formation."The corrected sentence appears below:"Results: The 30-day mortality rate of 67 patients with BSIs was 55.22%. Patients in the death group had significantly lower platelet counts and higher CRP levels than those in the survival group. Additionally, higher rates of antibiotic use (≥2 classes) and greater carbapenem exposure were observed. Among the isolates, CRAb accounted for 80.6%, ST2 accounted for 76.12%, and KL2/3/7/77/160 accounted for 65.67%. The predominant KL type was KL3, found in 19.4% of the isolates. All ST2 and KL2/3/7/77/160 isolates were CRAb. Among the isolates, 90.7% of the CRAb isolates coharbored blaOXA-23 and blaOXA-66, while one coharbored blaNDM-1 and blaOXA-23. Compared with non-ST2 and non KL2/3/7/ 77/160 infections, ST2 and KL2/3/7/77/160 infections had higher mortality rates (66.0% vs. 23.5%, P=0.002; 65.90% vs. 34.78%, P=0.015). Patients with ST2 and KL2/3/7/77/160 infections underwent more invasive procedures, received two or more antibiotics and carbapenem therapy before isolation, and had lower serum albumin levels. These isolates exhibited significantly higher resistance to antimicrobial agents. No significant differences in virulence phenotypes were observed between the two groups, except for biofilm formation between the ST2 and non-ST2 groups (P=0.035). However, these isolates harbored more virulence genes related to iron uptake and biofilm formation.