Editorial: Exploring Zoonoses: Therapeutic Strategies and Drug Mechanisms

Lei Tan ^1* Ma Mingxiao ² Zhanbo Zhu ³ Shen Yang ⁴

• ¹ Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China
• ² College of Animal Science and Veterinary Medicine, Jinzhou Medical University, Jinzhou, Liaoning Province, China
• ³ Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang Province, China
• ⁴ Cedars Sinai Medical Center, Los Angeles, California, United States

of the IL-17 signaling pathway plays a key role in mediating the antiviral effects of rosmarinic acid. This work not only validates the antiviral efficacy of a plant-derived compound but also underscores the importance of integrating computational predictions with experimental validations in the drug discovery process. https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2024.1396279/full Broader Implications and Future Directions Collectively, the contributions in this Research Topic showcase diverse strategies in combating zoonotic pathogens-ranging from the use of natural compounds to innovative antiviral paradigms. They emphasize the importance of a multidisciplinary approach that bridges natural product research, molecular biology, and pharmacology. As multidrugresistant bacteria and emerging viruses continue to challenge current therapeutic modalities, the development of alternative strategies is imperative. Future research should build upon these promising findings by further elucidating the molecular mechanisms underlying the observed therapeutic effects. For instance, deeper exploration into the synergistic interactions of natural compounds may refine their clinical application, while continued investigation into the use of DIPs and the detailed pathways modulated by melatonin and rosmarinic acid could lead to novel antiviral interventions. Ultimately, these studies highlight the value of integrating traditional medicine with modern molecular techniques-a synergy that holds significant promise for future drug development.The articles featured in this Research Topic not only advance our understanding of therapeutic strategies against zoonotic diseases but also pave the way for innovative approaches in both human and veterinary medicine. I extend my sincere gratitude to all contributing authors and the dedicated reviewers whose efforts have been invaluable in shaping this collection. It is my hope that the insights and discoveries presented here will stimulate further interdisciplinary collaboration and drive the next wave of innovations in the treatment and prevention of zoonoses.