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ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Parasite and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1568563
A machine learning-based text mining of cutaneous myiasis and potential value of an accidental maggot therapy to complicated skin and soft tissue infection with sepsis
Provisionally accepted- Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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BackgroundCutaneous myiasis, one of the most frequently diagnosed myiasis types, is identified as skin or soft tissue on a living host infested by dipterous larvae (maggots). However, bibliometric analysis of this disease remains sparse. Increasing interests of machine learning techniques and updated publications provides an opportunity to such investigation. Materials and methodsAll the studies were retrieved from PubMed and were processed by R software in bibliometric analysis and Latent Dirichlet Allocation (LDA) topic modeling. Meanwhile, clinical management of two diabetes patients with serious soft tissue infection-associated sepsis were analyzed. ResultsA total of 211 results were retrieved. Fifty topics relevant to cutaneous myiasis were determined by LDA algorithm. The topics of uncommon fly species, nasal infestation and physician discussion of cutaneous myiasis were consistently common for the last 20 years. Case report remains one of the key features in myiasis. Four major clusters were identified, i.e. case report related, disease type and development, travel in the tropics and skin disease. To further delve into clinical practice, clinical features of two patients with soft tissue infection related sepsis were demonstrated, and the distinct beneficial role of myiasis was noticed. Levels of white blood cell, blood glucose and c-reactive protein of the case with cutaneous myiasis were more stable than the other case without cutaneous myiasis but with sepsis shock. Conclusion Maggot debridement therapy may show promising and beneficial to soft tissue infection-related sepsis. Model analysis of maggot therapy and the clinical advantages shows increasing research values and future clinical practice.
Keywords: Bibliometric, diabetes, cutaneous myiasis, Latent Dirichlet Allocation, Soft tissue infection
Received: 30 Jan 2025; Accepted: 08 Apr 2025.
Copyright: © 2025 Zhiyuan, Yu, Yao, Wang, Huang, Wang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yousheng Li, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
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