94% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1566290
This article is part of the Research Topic Exploring the Interplay Between Microbiota, Gut, and Brain in Inflammatory Bowel Disease View all articles
Symphony of the Gut Microbiota and Endocannabinoidome: A Molecular and Functional Perspective
Provisionally accepted- Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
This review examines the impact of interactions between the gut microbiota and the endocannabinoidome (eCBome) on health and disease, highlighting their significance for physiological and pathological processes. We identify key research gaps and challenges to advance the field.The review discusses the role of dietary patterns and physical activity in regulating these interactions . It also explores the complex nature of these interactions in conditions such as inflammatory bowel disease (IBD), depression, anxiety, Alzheimer's disease (AD), and metabolic disorders. This analysis evaluates their contributions to disease onset and progression, and examines the molecular mechanisms and signaling pathways involved. From this, we provide forward-looking perspectives on future research directions, advocating for a more nuanced understanding of the gut microbiota -eCBome axis. We anticipate that future research will integrate gut microbiotaendocannabinoidome interactions into therapeutic strategies for a broad range of diseases.
Keywords: Endocannabinoid system (ECS), Endocannabinoidome (eCBome), Gut Microbiota, Symphony, interactions
Received: 24 Jan 2025; Accepted: 10 Mar 2025.
Copyright: © 2025 Wang, Guo, Mao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Chen, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.