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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1565103
This article is part of the Research TopicNew Insights into Gut Microbiota in Colorectal CancerView all 3 articles
Progress on the mechanism of intestinal microbiota against colorectal cancer
Provisionally accepted- 1Medical School, Tianjin University, tianjin, China
- 2Binhai Hospital, Peking University, Tianjin, China
- 3Tianjin University of Traditional Chinese Medicine, Tianjin, China
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The intestinal microbiota plays a crucial role in the occurrence and development of colorectal cancer, and its anti -colorectal cancer mechanism has become a research hotspot. This article comprehensively expounds on the molecular mechanisms of the intestinal microbiota in anti -colorectal cancer, including aspects such as immune regulation, activation of carcinogenic signaling pathways (it should be noted that it is more reasonable to be "inhibition of carcinogenic signaling pathways"), metabolite -mediated effects, and maintenance of intestinal barrier function. At the same time, it explores the roles and potential mechanisms of intervention methods such as probiotic supplementation therapy, immunotherapy, and fecal microbiota transplantation. In addition, it analyzes the impact of the intestinal flora on the therapeutic efficacy of colorectal cancer. The existing research results are summarized, and the future research directions are prospected, with the aim of providing new theoretical bases and treatment ideas for the prevention and treatment of colorectal cancer.
Keywords: Gut Microbiota, colorectal cancer, mechanism of action, Immune Regulation, study progress
Received: 22 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Xing, Cui, Guo, Han and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guogang Zhao, Binhai Hospital, Peking University, Tianjin, 300450, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.