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SYSTEMATIC REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1564362
ASSOCIATION BETWEEN ORAL DYSBIOSIS AND PARKINSON'S DISEASE: A SYSTEMATIC REVIEW
Provisionally accepted- 1Catholic University San Antonio of Murcia, Guadalupe, Murcia, Spain
- 2Faculty of Medicine, University of Murcia, Murcia, Murcia, Spain
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The oral cavity serves as the gateway to the human organism, hosting a diverse community of microorganisms that coexist in a state of symbiosis. Disruption of this balance leads to oral dysbiosis, a condition associated with infections and oral pathologies, which may contribute to the etiopathogenesis of systemic disorders such as Parkinson's disease, a neurodegenerative movement disorder characterized by resting tremor, rigidity, and bradykinesia. While oral dysbiosis is recognized as a risk factor and an aggravating element for Parkinson's disease, it is not regarded as a direct cause. This systematic review aims to synthesize existing research exploring the potential relationship between oral dysbiosis and the development of Parkinson's disease. Following a comprehensive analysis, 12 studies were selected, comprising 11 case-control studies and one observational analytical study. These studies investigated the composition of oral microbiota in different sample groups, revealing a higher abundance of pathogenic oral bacteria in individuals diagnosed with Parkinson's disease. The findings suggest that oral dysbiosis may influence both the onset of Parkinson's disease and the progression of symptoms such as cognitive decline. These results pave the way for future research, particularly regarding alterations in oral microbiota as potential biomarkers for early diagnosis and disease monitoring. Con formato: Inglés (Estados Unidos) Código de campo cambiado Con formato: Inglés (Estados Unidos
Keywords: Parkinson, Disease, oral dysbiosis, neurodegenerative, Systematic review
Received: 21 Jan 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Murcia-Flores, Sánchez-García, Pecci Lloret and Rodríguez-Lozano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Pilar Pecci Lloret, Faculty of Medicine, University of Murcia, Murcia, 30100, Murcia, Spain
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