95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Clinical Microbiology
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1560634
Genomic epidemiology of a novel Pandoraea pneumonica group caused severe bloodstream infection in Hainan, China, 2021-2024
Provisionally accepted
Chong Chen 1
Min Wang 2 Tao Huang 2 Dong-Liang Huang 3 Shuai Yu 4 Hui-Min Zhao 5
Xiangxiang Fu 6 Xin-Xin Li 6
Hua Wu 5*- 1 Hainan Second People's Hospital, Wuzhishan, Hainan Province, China
- 2 Hainan General Hospital, Haikou, Hainan Province, China
- 3 Hainan Armed Police Force Hospital, Haikou, China
- 4 Hainan Hospital of PLA General Hospital, Sanya, China
- 5 Hainan Affiliated Hospital of Hainan Medical University, Haikou, China
- 6 Hainan Medical University, Haikou, Hainan Province, China
Pandoraea is usually found in patients with cystic fibrosis. However, bloodstream infections (BSI) caused by it has rarely been reported. This study reported an outbreak of Pandoraea pneumonica in 30 patients with BSI in Hainan, China, from October 2021 to April 2024. Of the 30 clinical cases, five (16.67%) ultimately died, whereas 25 (83.33%) are alive. All isolates were identified as P. pneumonica based on the 16S rRNA-based phylogenetic analysis. However, obvious genetic differences were observed between the tested isolates and P. pneumonica Strain LMG 31114, suggesting that the outbreak's causative pathogen could be a novel cluster of P. pneumonica. The genomes accumulated mutations at an estimated rate of 1.3 × 10 -7 mutations/year/site. Moreover, 26 clinical isolates within the P. pneumonica cluster were formed in July 2014, revealing a tendency to develop regional endemic patterns.This study contributed to the basis on pathogen identification, disease diagnosis, and BSI treatment.
Keywords: Pandoraea pneumonica, Bloodstream infection, Whole-genome sequencing, pan-genome analysis Data summary, China
Received: 14 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Chen, Wang, Huang, Huang, Yu, Zhao, Fu, Li and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hua Wu, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.