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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Oral Microbes and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1556688
This article is part of the Research TopicDental diseases: In the spotlight of oral microbiome and host immune defenses - New approaches for Oral Health and Oral CareView all articles
Innovative Strategies Targeting Oral Microbial Dysbiosis: Unraveling Mechanisms and Advancing Therapies for Periodontitis
Provisionally accepted- Zunyi Medical University, Zunyi, China
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Periodontitis, a prevalent inflammatory oral disease, is intricately linked to disruptions in the oral microbiome, a state known as microbial dysbiosis. This review explores the pivotal roles of key pathogens, including Porphyromonas gingivalis and Tannerella forsythia, in driving periodontitis and examines the underlying molecular mechanisms that disrupt microbial homeostasis. We discuss how interactions among bacterial species affect the oral ecosystem's balance and how microbial metabolites influence the host immune responses, contributing to disease progression. Leveraging these insights, we propose cutting-edge therapeutic approaches aimed at restoring microbial equilibrium. These include personalized pharmacological interventions tailored to individual microbiome profiles and innovative microbiome-targeted strategies such as probiotic formulations and bacteriophage therapy. By precisely modulating microbial communities, these strategies hold promise for enhancing treatment efficacy, preventing disease recurrence, and mitigating issues like antimicrobial resistance. Overall, this review paves the way for novel prevention and management techniques in periodontitis, offering significant improvements in oral health outcomes for patients.
Keywords: oral microbiome, Microbial dysbiosis, Periodontitis, mechanistic insights, Therapeutic strategies inflammatory response
Received: 07 Jan 2025; Accepted: 08 Apr 2025.
Copyright: © 2025 Li, He, Luo, Zhao, Bai and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Delin Xu, Zunyi Medical University, Zunyi, China
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