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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1554753
This article is part of the Research Topic Immune Insights into Orthopedic Infections: Mechanisms, Biomarkers, and Prevention View all 8 articles
Micro/nano-structured titanium surfaces: Advances in anti-infection modification
Provisionally accepted- Liaoning University of Traditional Chinese Medicine, Shenyang, China
Titanium, its alloys, and their surface modification technologies have consistently been subjects of great enthusiasm among orthopedic surgeons. Nevertheless, orthopedic infections-primarily attributed to the biologically inert surface of titanium alloys and their lack of intrinsic antibacterial properties-represent the second leading cause of implant failure in clinical practice. Surface micro-/nano-structured (MNS) modifications of titanium alloys have gained significant attention as a promising strategy to impart multifunctional biological properties to these materials. Such modifications promote osteogenesis, modulate immunity, and enhance antibacterial properties.Furthermore, the micro-and nano-structured surfaces can serve as carriers for drug delivery, further mitigating the risk of orthopedic infections. This review provides a comprehensive overview of recent advancements in anti-infection strategies for titanium alloys with MNS surfaces. It emphasizes strategies such as drug loading, anti-adhesion surfaces, and stimulus-response systems, providing important guidance for advancing next-generation anti-infection orthopedic implants.
Keywords: Titanium, micro-/nano-structured, Anti-infection, Surface modification, Stimulusresponse
Received: 02 Jan 2025; Accepted: 03 Feb 2025.
Copyright: © 2025 Zhou, Wang, Li and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiayi Zhou, Liaoning University of Traditional Chinese Medicine, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.