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ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1524987
This article is part of the Research Topic Gut Microbiota and Age-Related Disorders: From Mechanisms to Therapies View all 4 articles
Multi-Omics Assessment of Gut Microbiota in Circadian Rhythm disorders: A Cross-Sectional Clinical Study
Provisionally accepted
Yanling Wei 1*
Yuting Tian 1 Rong Zhao 1 Shili Xiao 1 Lu Chen 1 Yi Cheng 1 Wei Meng 1 Zongyuan Tang 1
Yi Cai 2 Zhifeng Xiao 1 Ailin Yi 1 Minjia Chen 1 Xuefei Zhao 1 Guangcong Ruan 1- 1 Department of gastroenterology, Daping Hospital, Army Medical University, Chongqing, China
- 2 Xbiome, shenzhen, China
The interaction between the host and microbiota is influenced by host circadian rhythm. However, it is unknown what the changes of gut microbiota and metabolites. We conducted a cross-sectional study (n=72) in which participants’ fecal DNA was detected by macrogenomic sequencing analysis. The feces, urine and blood were analyzed by widely targeted metabolomics analysis. Pearson correlation analysis showed that most of the clinical symptoms of people with circadian rhythm disorders were moderately positively correlated with gastrointestinal symptoms. By distilling the results of multinomic analysis, we reported a variety of different species (19 species in the gut) and metabolites. In our results, the correlation of multiomics is mostly concentrated in Lachnospiraceae bacterium and Streptococcus mitis oralis pneumoniae. Bile acid-related metabolites are the most significant metabolites associated with these species. Our study demonstrates the severity of clinical manifestations caused by circadian rhythm disorder is closely related to microbiota and metabolism.
Keywords: Gut Microbiota, Circadian rhythm disorder, Metabolites, Cross-sectional study, Multiomics analysis
Received: 08 Nov 2024; Accepted: 28 Feb 2025.
Copyright: © 2025 Wei, Tian, Zhao, Xiao, Chen, Cheng, Meng, Tang, Cai, Xiao, Yi, Chen, Zhao and Ruan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanling Wei, Department of gastroenterology, Daping Hospital, Army Medical University, Chongqing, China
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