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ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 |
doi: 10.3389/fcimb.2025.1523863
Characteristics of Gut Microbiota and Metabolites in Extrahepatic Cholangiocarcinoma and Their Prognostic Value for Resectable Lesions
Provisionally accepted
Cheng Ye 1,2*
Bo Zhang 2
YAN YAN LIN 1,2
Fangfang Han 1,2 Huaqing Shi 1
Chunlu Dong 1,2
Wence Zhou 1,3*- 1 The First Clinical Medical College, Lanzhou University, Lanzhou, China
- 2 Department of General Surgery, First Hospital of Lanzhou University, Lanzhou, Gansu Province, China
- 3 Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
This study aimed to investigate the relationship between gut microbiota composition, fecal metabolites, and postoperative prognosis in patients with extrahepatic cholangiocarcinoma (eCCA). A total of 53 patients with resectable eCCA and 21 healthy volunteers as a control group were included. 16S rRNA gene sequencing and metabolomic analyses revealed significant differences in the gut microbial community structure and altered fecal metabolites profiles between eCCA patients and healthy controls. Univariate and multivariate Cox regression analyses indicated that factors such as preoperative total bilirubin, indirect bilirubin, and specific metabolites were closely associated with overall survival in patients with eCCA post-surgery. The constructed nomogram model further demonstrated the predictive value of these factors, achieving a C-index of 0.718, with calibration curves confirming its strong predictive performance. In conclusion, gut microbiota composition and fecal metabolites play a crucial role in the surgical prognosis of eCCA patients, providing new insights for clinical prognostic assessment.
Keywords: Extrahepatic cholangiocarcinoma, Gut Microbiota, Metabolites, Postoperative prognosis, Predictive Value
Received: 06 Nov 2024; Accepted: 28 Jan 2025.
Copyright: © 2025 Ye, Zhang, LIN, Han, Shi, Dong and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Cheng Ye, The First Clinical Medical College, Lanzhou University, Lanzhou, China
Wence Zhou, The First Clinical Medical College, Lanzhou University, Lanzhou, China
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