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REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Microbes and Innate Immunity
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1518659
This article is part of the Research Topic Respiratory Pathogen Infection and Host Innate Immune Response View all 3 articles
L-serine metabolic regulation and host respiratory homeostasis
Provisionally accepted- 1 Department of Environment and Safety Engineering,, Taiyuan Institute of Technology, Taiyuan, Shanxi, China
- 2 College of Pharmacy, Army Medical University, Chonqing, China
- 3 School of Veterinary Medicine, Southwest University, Chongqing, Chongqing Municipality, China
- 4 College of Agronomy and Biotechnology, Southwest University, Chongqing, China
L-Serine, a non-essential amino acid (NEAA), can be obtained through diet or in situ synthesis. Functionally, L-serine not only serves as the precursor of other amino acids, lipids, and nucleotides, but also participates in the folate/methionine cycle. An increasing number of studies have demonstrated that L-serine is widely used in the adjuvant therapy of many diseases (e.g., inflammation, infections, fibrosis, and tumors). Here, we summarize the synthesis and metabolism of serine followed by its functions in health and disease. Moreover, we delineate the potential mechanisms whereby L-serine is involved in the occurrence and progression of respiratory diseases. This review aims to summarize the research progress of serine in diseases, propose the problems that need to be solved in the future, and provide guidance for subsequent research and development.
Keywords: Serine, Inflammation, Infection, Respiratory diseases, PHGDH
Received: 28 Oct 2024; Accepted: 10 Feb 2025.
Copyright: © 2025 Li, Wu, Huang, Qin, Xiong and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Pan Li, Department of Environment and Safety Engineering,, Taiyuan Institute of Technology, Taiyuan, 030008, Shanxi, China
Yangyang Qiu, School of Veterinary Medicine, Southwest University, Chongqing, 402460, Chongqing Municipality, China
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