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ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Extra-intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1514510
This article is part of the Research TopicMicrobial Dysbiosis and Immune Dysregulation in Periodontitis and Peri-ImplantitisView all 7 articles
Analysis of the diversity and function of the microbiota in infected root canals of type 2 diabetes mellitus with apical periodontitis
Provisionally accepted- 1Guang'an People's Hospital, Guang'an, China
- 2Peking University Hospital of Stomatology, Beijing, China
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Purpose: This study aimed to compare the compositional differences and functions of microbial communities in infected root canals of teeth with apical periodontitis (AP) and/or type 2 diabetes mellitus (T2DM) using 16S rDNA sequencing.Methods: Eighteen participants were categorized into two groups based on their health conditions: AP and AP complicated with T2DM (APDM). Infected root canal microbiota was clinically collected for 16S rDNA sequencing. Subsequent statistical and bioinformatics analyses were conducted after sequencing by NovaSeq, encompassing diversity analysis, intergroup difference analysis, and functional prediction analysis.The core microbiome of root canal microorganisms was similar in the two groups, which mainly consisted of Bacteroidota,
Keywords: apical periodontitis, type 2 diabetes mellitus, root canal, microbiome, Sequencing
Received: 21 Oct 2024; Accepted: 11 Apr 2025.
Copyright: © 2025 Li, Wu, Zhang, Zhang, Hu, Zhang, Yang, Xiong and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yong Zhang, Peking University Hospital of Stomatology, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.