ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1509180
This article is part of the Research TopicMolecular mechanisms and clinical studies of multi-organ dysfunction in sepsis associated with pathogenic microbial infectionView all 11 articles
Characteristics and prognosis of patients with pathogenic microorganism-positive sepsis AKI from ICU: A retrospective cohort study
Provisionally accepted
- 1Kaifeng Central Hospital, Kaifeng, Henan Province, China
- 2Dalian University, Dalian, Liaoning Province, China
- 3Shenzhen Hospital, Peking University, Shenzhen, Beijing Municipality, China
- 4Anhui Medical University, Hefei, China
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Background: Sepsis-associated acute kidney injury (SA-AKI) carries a disproportionately high morbidity and mortality rate. While the synergism between dysregulated host response and renal vulnerability is increasingly recognized, the multifactorial drivers of poor prognosis remain poorly defined.. The purpose of this study was to investigate the prognosis and clinical characteristics of patients with pathogenic microorganism-positive SA-AKI.Method: Using a retrospective analysis approach, We extracted populations from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database that fulfilled the diagnostic criteria for confirmed sepsis with microbiological evidence of pathogenic organisms, and patients were divided into two cohorts according to with or without AKI. The severity of the disease in the two groups was collected for evaluation, and the clinical indicators and prognostic results of the patients were evaluated. The objective of this study was to explore the risk factors affecting the prognosis of patients with pathogenic microorganism-positive SA-AKI.The hospital mortality rate of AKI in patients with pathogenic microbial-positive sepsis was 18.96%. Further analysis showed that the use of vasoactive drug therapy, high of lactate level, SAPS II score, SAPS III score and LODS score, and clinical indicators of prolonged hospital stay were independent risk factors for in-hospital mortality in patients with pathogenic microorganism-positive SA-AKI. Among them, SAPS III score plays an important role in predicting the prognosis of sepsis patients with AKI. Further studies found that lactate level was positively correlated with SAPS II score, SAPS III score and and LODS score.The use of vasoactive drug therapy, high of lactate level, SAPS II score, SAPS III score and LODS score plays an important role in assessing the prognosis of patients with pathogenic microorganism-positive SA-AKI, multivariate comprehensive assessment play a significance for predicting the prognosis of sepsis AKI patients.
Keywords: Positive for pathogenic microorganisms, Sepsis, acute kidney injury (AKI), prognosis, SAPS III；Risk factors
Received: 10 Oct 2024; Accepted: 22 Apr 2025.
Copyright: © 2025 Jin, Meng, Zhou and Chao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Chao, Anhui Medical University, Hefei, China
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