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ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Biofilms
Volume 15 - 2025 |
doi: 10.3389/fcimb.2025.1507486
This article is part of the Research Topic Fighting Microbial Biofilms: Novel Therapeutics and Antibiofilm Strategies View all 11 articles
A Novel Mechanism for Eradication of Staphylococcal Biofilms Using Blood Clots
Provisionally accepted- Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, United States
Infections with coagulase negative staphylococcal species (CoNS) are a major cause of mortality and morbidity in joint and heart valve replacement procedures, largely due to biofilm formation. Cells within biofilms have higher rates of antibiotic resistance than their planktonic counterparts; consequently, novel mechanisms are needed to combat these infections. To enhance antibiotic delivery and penetration, this innovative study involved treating CoNS biofilms with murine blood clots impregnated with antibiotics. Indeed, our pilot study demonstrates that this method of antibiotic delivery results in improved biofilm clearance, relative to conventional exposure methods. It also demonstrates that blood clot exposure has an intrinsic impact on biofilm density and potentially reduces colonization.
Keywords: biofilm1, antibiotic resistance2, staphylococci3, prosthetic joint infections4, Biomaterials5
Received: 07 Oct 2024; Accepted: 09 Jan 2025.
Copyright: © 2025 Grooters, Hayes, Richter, Ku, Sawyer and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kayla Elizabeth Grooters, Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, United States
Yong Li, Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, United States
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